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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1950 1
1960 1
1963 1
1964 1
1968 2
1969 2
1970 2
1971 1
1972 1
1973 1
1974 2
1975 8
1976 17
1977 15
1978 14
1979 22
1980 25
1981 10
1982 21
1983 36
1984 31
1985 33
1986 28
1987 56
1988 56
1989 76
1990 92
1991 120
1992 119
1993 154
1994 164
1995 195
1996 222
1997 223
1998 266
1999 296
2000 328
2001 376
2002 423
2003 498
2004 573
2005 690
2006 855
2007 907
2008 1098
2009 1095
2010 1238
2011 1345
2012 1477
2013 1627
2014 1813
2015 1840
2016 1670
2017 1843
2018 2025
2019 2251
2020 2368
2021 2498
2022 2525
2023 2412
2024 836

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Search Results

33,036 results

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Page 1
Platelet signaling-a primer.
Goggs R, Poole AW. Goggs R, et al. J Vet Emerg Crit Care (San Antonio). 2012 Feb;22(1):5-29. doi: 10.1111/j.1476-4431.2011.00704.x. Epub 2012 Feb 3. J Vet Emerg Crit Care (San Antonio). 2012. PMID: 22316389 Review.
OBJECTIVE: To review the receptors and signal transduction pathways involved in platelet plug formation and to highlight links between platelets, leukocytes, endothelium, and the coagulation system. ...CONCLUSIONS: Improvements in our understanding of how platelets …
OBJECTIVE: To review the receptors and signal transduction pathways involved in platelet plug formation and to highlight links …
Identification of ligand-receptor pairs that drive human astrocyte development.
Voss AJ, Lanjewar SN, Sampson MM, King A, Hill EJ, Sing A, Sojka C, Bhatia TN, Spangle JM, Sloan SA. Voss AJ, et al. Nat Neurosci. 2023 Aug;26(8):1339-1351. doi: 10.1038/s41593-023-01375-8. Epub 2023 Jul 17. Nat Neurosci. 2023. PMID: 37460808 Free PMC article.
Extrinsic signaling between diverse cell types is crucial for nervous system development. ...Our data-driven framework can leverage single-cell and bulk genomic data to generate and test functional hypotheses surrounding cell-cell communication regulating neu …
Extrinsic signaling between diverse cell types is crucial for nervous system development. ...Our data-driven framework can leverage s …
Engineered gene circuits.
Hasty J, McMillen D, Collins JJ. Hasty J, et al. Nature. 2002 Nov 14;420(6912):224-30. doi: 10.1038/nature01257. Nature. 2002. PMID: 12432407 Review.
A central focus of postgenomic research will be to understand how cellular phenomena arise from the connectivity of genes and proteins. ...These developments have signalled the emergence of a gene circuit discipline, which provides a framework for predicting and eva …
A central focus of postgenomic research will be to understand how cellular phenomena arise from the connectivity of genes and protein …
Imaging cAMP nanodomains in the heart.
Chao YC, Surdo NC, Pantano S, Zaccolo M. Chao YC, et al. Biochem Soc Trans. 2019 Oct 31;47(5):1383-1392. doi: 10.1042/BST20190245. Biochem Soc Trans. 2019. PMID: 31670375 Free PMC article. Review.
The specific local control at these nanodomains is enabled by a distinct signalosome where effectors, targets, and regulators of the cAMP signal are clustered. In this review, we focus on recent advances using targeted fluorescent reporters for cAMP and how they have contr …
The specific local control at these nanodomains is enabled by a distinct signalosome where effectors, targets, and regulators of the cAMP …
Mindfulness meditation and gene expression: a hypothesis-generating framework.
Black DS, Christodoulou G, Cole S. Black DS, et al. Curr Opin Psychol. 2019 Aug;28:302-306. doi: 10.1016/j.copsyc.2019.06.004. Epub 2019 Jul 11. Curr Opin Psychol. 2019. PMID: 31352296 Free PMC article. Review.
Mindfulness meditation is a consciousness discipline used to cultivate attention and self-regulation, and may thus be relevant to the signal transduction process outlined in the social genomics literature. ...In the spirit of hypothesis generation, we argue t …
Mindfulness meditation is a consciousness discipline used to cultivate attention and self-regulation, and may thus be relevant to the sig …
Identification of ligands for bacterial sensor proteins.
Fernández M, Morel B, Corral-Lugo A, Rico-Jiménez M, Martín-Mora D, López-Farfán D, Reyes-Darias JA, Matilla MA, Ortega Á, Krell T. Fernández M, et al. Curr Genet. 2016 Feb;62(1):143-7. doi: 10.1007/s00294-015-0528-4. Epub 2015 Oct 28. Curr Genet. 2016. PMID: 26511375 Review.
Bacteria have evolved a variety of different signal transduction mechanisms. However, the cognate signal molecule for the very large amount of corresponding sensor proteins is unknown and their functional annotation represents a major bottleneck in the field …
Bacteria have evolved a variety of different signal transduction mechanisms. However, the cognate signal molecule for t …
Targeted biopharmaceuticals for cancer treatment.
Zhou L, Xu N, Sun Y, Liu XM. Zhou L, et al. Cancer Lett. 2014 Oct 1;352(2):145-51. doi: 10.1016/j.canlet.2014.06.020. Epub 2014 Jul 9. Cancer Lett. 2014. PMID: 25016064 Review.
Aetiology and management of hereditary aortopathy.
Verstraeten A, Luyckx I, Loeys B. Verstraeten A, et al. Nat Rev Cardiol. 2017 Apr;14(4):197-208. doi: 10.1038/nrcardio.2016.211. Epub 2017 Jan 19. Nat Rev Cardiol. 2017. PMID: 28102232 Review.
As such, perturbed extracellular matrix homeostasis, transforming growth factor-beta signalling, and vascular smooth muscle cell contractility have been proposed as important processes in TAA pathogenesis. These new insights enable novel treatment options that are currentl …
As such, perturbed extracellular matrix homeostasis, transforming growth factor-beta signalling, and vascular smooth muscle cell cont …
Tools for GPCR drug discovery.
Zhang R, Xie X. Zhang R, et al. Acta Pharmacol Sin. 2012 Mar;33(3):372-84. doi: 10.1038/aps.2011.173. Epub 2012 Jan 23. Acta Pharmacol Sin. 2012. PMID: 22266728 Free PMC article. Review.
G-protein-coupled receptors (GPCRs) mediate many important physiological functions and are considered as one of the most successful therapeutic targets for a broad spectrum of diseases. The design and implementation of high-throughput GPCR assays that allow the cost-effect …
G-protein-coupled receptors (GPCRs) mediate many important physiological functions and are considered as one of the most successful therapeu …
[Signaling network-based functional cell design].
Ju J, Wei P. Ju J, et al. Sheng Wu Gong Cheng Xue Bao. 2017 Mar 25;33(3):386-392. doi: 10.13345/j.cjb.160450. Sheng Wu Gong Cheng Xue Bao. 2017. PMID: 28941338 Free article. Review. Chinese.
Cellular signaling networks act as the central processor to deal with environmental signals and regulate cell function, and determine cell fate. ...Here, we first review the research progresses on the signaling coding mechanisms; and then elaborate the …
Cellular signaling networks act as the central processor to deal with environmental signals and regulate cell function, and de …
33,036 results
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